Peptide targeting of lysophosphatidylinositol-sensing GPR55 for osteoclastogenesis tuning
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چکیده
منابع مشابه
Peptide-guided targeting of GPR55 for anti-cancer therapy
Expression of the lysophosphatidylinositol receptor GPR55 correlates with invasive potential of metastatic cells and bone metastasis formation of different types of tumors. These findings suggest a role for GPR55 signaling in cancer progression, including in lymphoproliferative diseases. Here, we screened a M13-phage-displayed random library using the bait of HEK293 cells that heterologously ex...
متن کاملGPR55, a G-Protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination
The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology. However, little is known about the role of GPR55 in CNS development and function. To address this question, we performed a detailed characterization of GPR55 knockout mice using mol...
متن کاملMinireview: recent developments in the physiology and pathology of the lysophosphatidylinositol-sensitive receptor GPR55.
Emerging data suggest that off-target cannabinoid effects may be mediated via novel seven-transmembrane spanning/G protein-coupled receptors. Due to its cannabinoid sensitivity, the G protein-coupled receptor 55 (GPR55) was recently proposed as a candidate; however, GPR55 is phylogenetically distinct from the traditional cannabinoid receptors, and the conflicting pharmacology, signaling, and fu...
متن کاملGPR55-dependent and -independent ion signalling in response to lysophosphatidylinositol in endothelial cells
BACKGROUND AND PURPOSE The glycerol-based lysophospholipid lysophosphatidylinositol (LPI) is an endogenous agonist of the G-protein-coupled receptor 55 (GPR55) exhibiting cannabinoid receptor-like properties in endothelial cells. To estimate the contribution of GPR55 to the physiological effects of LPI, the GPR55-dependent and -independent electrical responses in this cell type were investigate...
متن کاملModulation of L-α-lysophosphatidylinositol /gpr55 Map Kinase Signalling by Cannabinoids
School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK; Division of Medical Sciences, Ninewells Hospital and Medical School, University of Dundee, DD1 9SY, UK; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, CH-3012, Bern, Switzerland; Departments of Behavioral Sciences & Molecular Biology, Ar...
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ژورنال
عنوان ژورنال: Cell Communication and Signaling
سال: 2021
ISSN: 1478-811X
DOI: 10.1186/s12964-021-00727-w